Oocyte quality assurance | OVOGENE Donor Bank

How do we determine the quality of the donor egg?

Our team uses highly advanced technologies during egg quality determination and follows a quality assurance program. We share our protocols with all our partner clinics for donor egg retrieval, cumulus complex denudation, culturing, vitrification, transportation and the warming process.

According to our selection criteria, donor eggs need to pass the morphological quality, Spindle View and genetic verification assessments. Only after successfully passing the quality assessment process our expert embryology team decides which donor eggs to vitrify.

We conduct audits with all our partner clinics. We offer clinics the embryology laboratory quality assurance program, and our consultants will support clinics during the whole process.

Quality assurance practice of Ovogene

For all banking processes and laboratory quality standards, Ovogene abides by the following ESHRE (European Society Human Reproduction), ASRM (American Society of Reproductive Medicine) and CAP (College of American Pathologists) guidelines and criteria.

Our experienced egg donation team follows all the stated guidelines from medical processes, transportation and administrative processes under the quality assurance program for partner clinics and recipients.

Our assurance program includes 4 key points that our clinicians and partner clinics follow for the best success rates.

  • Warming Protocol

    The Ovogene embryology team will set up the warming protocol for partner clinics and support them with personal training.

  • Conduct IVF Audit

    Our laboratory team will monitor all aspects of the donation program and share the information with partner clinics.

  • Techniques used in Embryo Development

    Ovogene offers high-quality blastocyst outcomes and cleavage rates during embryo cultivation. We offer support to our partner clinics with practices and protocols.

  • Genetically Certified Oocytes

    We use a unique technology that allows us to analyze the genetic integrity of an oocyte. We offer genetically certified euploid oocytes, giving clients certainty about the genetic potential of a donor egg. Ovogene is proud to be the first in the world to give such an option to our partner clinics and recipients.

How do we grade donor oocytes for egg banking?

Morphological oocyte grading (scoring) is the key factor in determining the best survival and blastocyst rates. To ensure the best outcome for donor eggs, strict morphological criteria for oocyte selection are followed. At Ovogene, our team has built a stringent grading system that includes 3 steps:

  • Step

    After seeing cumulus complex denudation with the time-lapse video recording, we enlarge the oocyte image and determine all necessary morphological specifications.

  • Step

    We use Spindle View Imaging System to calculate the perivitelline space and cytoplasmic granulation.

  • Step

    We determine meiotic spindle maturation and location and save time-lapse images of the meiotic spindle location.

Oocyte of what grade do we freeze for egg banking?

  • Grade 1

    No cytoplasmic granulation, small perivitelline space, mature meiotic spindle, the exact size of zona pellucida.

  • Grade 2

    Presence of cytoplasmic granulation.

  • Grade 3

    PPresence of cytoplasmic granulation and large perivitelline space.

  • Grade 4

    Fragmented oocyte.

At Ovogene, we only freeze oocytes with Grade 1 quality morphology for egg banking! Our goal is to provide high survival rates, high blastocyst rates and a high clinical pregnancy outcome. We offer support during the donation program to all of our partners, clinics and individual patients. Our strategy is total transparency and traceability in front of our customers.

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