A special webinar on «How to Achieve a Successful Pregnancy After 40»

Greetings, cherished readers!

We have something exciting for you! Have you heard about our fantastic partner, Fertility Network UK? I will say a few words about them once more.

Whether trying to conceive, going through treatment, or living without kids, they are here to help you. They provide a wide range of resources and support since they are conscious there is no one size fits all approach concerning fertility.

Ovogene also assists those who wish to have children and move on with confidence. We can resolve issues and bring happiness to others due to modern artificial intelligence and advanced technology. The fact that we share the same objectives and viewpoints as our partner has led to a successful synergy in our cooperation with the UK's Fertility Network.

The webinar titled “How to achieve a successful pregnancy after 40” was produced as a consequence of this synergy. This webinar was organized by Dr. Uliana Dorofeyeva, our colleague and Director of Clinical Operations at Ovogene, and Sharon Martin, Business Development Manager at Fertility Network UK. They shared information on how to get pregnant as soon as it is safe and increase each patient's chance of success during their first cycle.

What Do You Need To Know About Reducing Multiple Pregnancies And Safety In IVF?

We lose our ability to reproduce annually. In the modern world, women prefer to take care of themselves, pursue their careers, and only then shift their attention back to family and having children. We should all be conscious that our biological clocks never stop ticking and that age plays a critical role. All the patterns indicate that we should be ready to handle concerns with older women's fertility. For this reason, we advise women to plan and freeze their oocytes while their reproductive potential is still high.

Women's reproductive capacity and the quality of their oocytes decline with age. One of the key factors contributing to repeated failures of assisted reproduction procedures is poor egg quality. Together with other elements found in the cytoplasm of the eggs, microscopic organelles called mitochondria (the cells' energy sources) play a significant role in determining the quality of the eggs.

What Else Causes Poor Egg Quality?

For instance: maternal age, ovarian, reserve genetic factors, or endometriosis − all of these factors can affect the success of a pregnancy. Due to delayed embryo development, patients with low egg quality have numerous unsuccessful IVF cycles and must be treated with traditional egg donation programs to become pregnant.

“What should one do in this circumstance? How to assist those women? Who has poor egg quality?”, Dr. Ulyana Dorofeeva specifically discussed that throughout the webinar. She informed us that spindle and pronuclear transfers are an alternative to egg donation.

What Does It Mean?

Spindle transfer is the replacement of the entire cytoplasm of poor−quality eggs. This procedure is based on transferring the spindle (containing the genetic material) of the egg from an affected woman into donor eggs with a healthy cytoplasm that had their spindle removed. The eggs resulting from the procedure with the repaired cytoplasm can then be inseminated by conventional techniques (ICSI) with the sperm of the patient’s partner, giving the intended parents a chance of having a child related to them genetically. It will provide families affected by the mitochondrial disease with an opportunity of having healthy children free of a devastating and often life−limiting disease!

The study suggests mitochondrial donation could prevent more than 12,400 women in the US from transmitting mitochondrial diseases, meaning at least 770 babies could be saved from these diseases annually. This number could increase in Europe and Asia.

Maternal spindle transfer has been tested on human eggs. The method led to the development of blastocysts − thin, hollow structures containing a cluster of cells that develop in early embryonic development! Less mechanical and morphological damage during manipulation!

And What About The Pronuclear Transfer?

PNT consists of in vitro fertilization using the eggs of the affected woman whose mitochondria contain mutant mtDNA and the sperm of the future father. The subsequent extraction of the pronucleus on day 1 of development leaves behind most of the mutated mitochondria. These pronuclei are transferred to an enucleated zygote with healthy mitochondria. They are transferred to an enucleated zygote since the developmental state must be the same. The hybrid zygote is then developed in vitro until it reaches an appropriate condition for transfer to the uterus. There is no risk of fertilization because transfer already between zygotes, a better blastocyst outcome.

A doctor's expertise and specialized cultivation methods are necessary for technique and mechanical micromanipulation. Dr. Ulyana Dorofeeva goes into great depth about this throughout the webinar.

Here is a link to this webinar! Click here.

Feel free to contact us with any questions or concerns.

We are open to considering each situation individually and support you while you work toward getting pregnant and having children!

Dec 22, 2022

by Genie

Digital IVF specialist & your virtual assistant at Ovogene

Contact us

Name
Phone number
Email
Message