Genetically Certified Oocyte® technology

OVOGENE Egg Donor Bank is the only bank in the world offering the unique service of Genetically Certified Oocyte® technology, this includes:

  • Oocyte NGS Screening- determines aneuploidy of oocytes via first polar body biopsy.

  • 100% euploid oocytes.

  • Higher blastocyst rates

  • Genetically Certified Oocyte® technology warrants a higher chance of getting pregnant from the 1st attempt*, avoiding numerous attempts.

  • Genetic laboratory certification.

*Numerous factors can influence pregnancy success rates- egg quality, sperm quality, experience of embryologist, patient's health conditions, lab equipment. We guarantee that the quality of eggs is appropriate to achieve a successful pregnancy, but we can not take responsibility for other independent factors.

What is Certified oocyte?

  • They are genetically screened eggs that have been found to have a normal chromosomal constitution. This can reassure individuals using donor eggs that the oocytes will be of better quality and therefore have a better chance of a successful pregnancy.

What does oocyte genetic error mean and how is it detected?

  • Genetic errors in the oocyte occur as a result of meiotic malsegregation during oogenesis. Polar body analysis is an important method in detecting these errors.
  • Female meiotic errors are the main cause of whole chromosomal aneuploidy in human embryos and significantly contribute to early embryo loss.

Why is it important to genetically screen the oocyte?

  • The genetic structure of an oocyte directly affects pregnancy success.
  • Aneuploidy embryos reduce pregnancy success or can lead to births with chromosomal abnormalities, such as Down syndrome.
  • Analysis of the polar body revealed that on average a third of the eggs from young females had genetic errors (Gianaroli et al., 2009).

What are the advantages of oocyte NGS testing?

  • The main advantages of using polar body biopsy is that there would be less discarded embryos, which would be more ethical and less traumatizing for many patients.

  • First and second polar bodies may not be required for further embryonic development, hence viability of the oocyte is not affected and resulting embryos are preserved.
Considering the problem of mosaicism, which is a major limitation of the embryo testing, the direct testing of oocytes by polar body analysis has practical value in improving accuracy and reliability of selecting euploid embryos for transfer (Anver Kuliev, 2011).
A constraint of polar body testing is that only maternally derived errors are identified. But it has been shown that approximately 95% of chromosomal errors originate from female meiosis alone (Anver Kuliev, 2011). Despite the limitations, polar body testing still provides detection of chromosomal irregularities and therefore the majority of aneuploid embryos can be avoided for transfer.

What about survival rates and IVF outcomes?

According to current research and statistics, almost 20-30% of donor eggs are aneuploidy (J. Horne, 2016).

Oocyte NGS Aneuploidy testing is unique, as it promises to differentiate between aneuploid and euploid oocytes. The aneuploidy testing aims to optimise the egg donation programme by only selecting the best quality, euploid oocytes. 

Euploid oocytes increase the probability of a euploid embryo, hence offer better survival rates. Oocyte testing will avoid the need for NGS embryo testing, therefore, patients can avoid the traumatic process of embryo biopsy, freezing and re-thawing again. No difference in survival rate has been identified among vitrified donor oocytes which have undergone biopsy and oocytes that have not.

OVOGENE Egg Donor Bank is able to offer better clinical outcomes for egg donation, with the use of euploid oocytes only. By avoiding using aneuploid oocytes, we can offer a more cost effective egg donation programme.

Obligatory tests, before purchasing programs with NGS screening :

  • *FISH sperm analysis, Karyotype
  • *Endometrium thickness receptivity
  • *Results of histeroscopy
  • *Sperm factors
  • Indicators of the spermogram - more than 1 million sp in ml
  • More than 1% are morphologically normal
  • Fr DNA within the norms of values
  • FISH sperm analysis
  • Karyotype - husband
  • The patient is up to 50 (55-?) Years old
  • Normal p-li hysteroscopies during the year
  • The minimum thickness for the 8th - 12th day of the cycle is 8 mm
  • Normal structure
  • In the absence of hystero - ultrasound and histology
  • Absence of serious autoimmune and general diseases such as Diabetes, hypertension, c \ c

Polar Body Biopsy and Aneuploidy testing

Blastomere testing for aneuploidy has an important limitation of extremely high rates of mosaicism at the cleavage stage. Most of the time, especially for egg donation programmes, blastocyst trophectoderm NGS testing is not very useful as the number of blastocysts are limited.  

Polar body biopsy is a sensitive process that requires intricate manipulation. For effective handling, a wealth of practical experience and theoretical knowledge is essential. Our scientific team has an abundance of expertise within polar body biopsy and oocyte aneuploidy testing with NGS. It is extremely important to have a strong and efficient vitrification (cryopreservation) process for the evaluated oocytes. A special vitrification protocol for polar body biopsied oocytes was designed by our dedicated team to guarantee high survival rates after the thawing process.

After polar body biopsy, we analyse the genetic aptitude of oocytes by NGS screening. Approximately 20% of high quality morphological donor oocytes exhibit aneuploidy.  Our ambition is to supply only euploid oocytes  to our customers, thus  increasing a patient’s chances of a clinical pregnancy. Euploid oocytes indicate a strong  potential for the fertilization, a high quality of euploid blastocysts and non-fragmented embryo development. Our customer have a unique opportunity to get only euploid oocytes, excluding aneuploid oocytes, for their egg donation programme.

Meiotic spindle determination before oocyte vitrification.

The probability of an oocyte having normal spindle and chromosomal configuration is 75%-80%. Consequently, approximately 20% of oocytes have an abnormal meiotic spindle or the meiotic spindle is located in a critical area, which may create damage during fertilization process such as ICSI. OVOGENE Egg Donor Bank only freezes oocytes with a normal meiotic spindle view, with this confirmed through special software. Also customers are able to get real-time pictures and the location of the meiotic spindle. This will help to avoid the risk of meiotic spindle damage during sperm injection by ICSI method.

Oocytes Freezing quality.

With time lapse camera microscopy, it is possible to show the quality of vitrification. The time lapse microscopy camera will create real time, HD quality images and you will be able to see oocyte activation in the vitrification and equilibration solution during cryopreservation. OVOGENE Egg Donor Bank aims for maximum transparency with our customers. Therefore, our client will be able to understand each process within donor egg vitrification. This provides assurance to our customers about our morphological selection criteria, the vitrification techniques of our embryologists and our well-constructed process for vitrification.



+44 204 577 0039

+1 202 864 1770

+38 044 379 3150



United Kingdom

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